Top-down view of the conformational transition in the extracellular domain from the unliganded to the mono-liganded, and then to the di-liganded state. (VIDEO)

University of Ottawa

Caption

A global alignment of the three states was done based on the C atoms in the M1-M3 helices from each subunit to visualize the motions of the extracellular domain relative to the transmembrane domain. A morph between the three states was created in ChimeraX (41).

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