Engineering therapeutic T cells with CRISPRoff (IMAGE)

Arc Institute

Engineering therapeutic T cells with CRISPRoff

Caption

This figure shows primary T cells modified using two approaches. CAR receptors are introduced through targeted DNA insertion (top), while CRISPRoff mRNA and guide RNAs silence additional genes through epigenetic modifications (bottom). This creates CAR-T cells with enhanced capabilities without the toxicity of cutting DNA at multiple sites.

Credit

Chiara Ricci-Tam

Usage Restrictions

Credit must be given to the creator. Adaptations must be shared under the same terms.

License

CC BY-SA

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.