Development of the spinal cord and the peripheral nerve system. (IMAGE)
Caption
(a) The various types of neurons in the spinal cord are distributed according to their anatomical locations. (b) The rostral–caudal (RC) axis of the spinal cord is established by gradients of RA, FGF8, and GDF11. (c) The dorsal–ventral (DV) axis of the spinal cord is established by gradients of WNTs, BMPs, and SHH, which give rise to different types of neurons that are distributed along this axis. (d) NCCs migrate to the periphery and give rise to ganglia and myelin in the peripheral nervous system. CNS: central nervous system; dI1–dI6: dorsal interneurons; FP: floor plate; MN: motor neuron; NC: notochord; PNS: peripheral nervous system; p0–p3: ventral progenitor domains; pd1–pd6: dorsal progenitor domains; pMN: motor neuron progenitor; RP: roof plate; V0d, V0v, V1, V2a, V2b, V3: ventral interneurons.
Credit
Jiaqi Su, Zhiwen Yan, Xiaoxuan Tang, Tong Wu, Jue Ling, Yun Qian
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CC BY-NC-ND