LD biogenesis and its contact sites. (IMAGE)
Caption
(A) The formation of cytoplasmic LDs in mammals involves four steps: neutral lipid synthesis, neutral lipid aggregation, new LD budding, and LD maturation. LD-associated proteins are generally classified into class I proteins from the endoplasmic reticulum (ER) and class II proteins (e.g., perilipins). (B) Cytoplasmic LDs can interact with intracellular organelles such as the ER, mitochondria, peroxisome, and lysosome. ABCD1, ATP binding cassette subfamily D member 1; ACSVL4, acyl-CoA synthetase long chain family member 4; ARL8B, ADP-ribosylation factor-like protein 8B; CPT1A, carnitine palmitoyltransferase 1A; DAG, diacylglycerol; DFCP1, double FYVE containing protein 1; DGAT, diacylglycerol transferase; FIT2, fat storage-induced transmembrane 2; HSC70, heat shock cognate protein; LDs, lipid droplets; MIGA2, mitoguardin 2; Snx, sorting nexin; TAG, triacylglycerol.
Credit
Xuwen Xiang, Jing Chen, Lin Che
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CC BY-NC-ND