Pharmacological Insights into Scleromitrion diffusum (Willd.) Against Gastric Cancer (IMAGE)
Caption
The anticancer potential of natural products has garnered increasing recognition in recent years. Exemplifying modernized research in TCM, S. diffusum demonstrates significant anti-neoplastic efficacy in both preclinical and clinical studies, highlighting the considerable promise of rigorous multidisciplinary integration. This review synthesizes two critical insights: S. diffusum contains multiple bioactive constituents that combat gastric cancer through diverse mechanisms, and beyond conventional approaches like apoptosis induction, proliferation suppression, and angiogenesis inhibition, emerging evidence reveals S. diffusum’s therapeutic actions via ferroptosis modulation and telomerase interference. These findings underscore S. diffusum’s substantial untapped potential for gastric cancer management, particularly through synergistic combinations of active compounds to discover novel anticancer pathways. Such advancements provide crucial empirical validation for TCM principles while propelling the development of precision herbal oncology frameworks.
Credit
Xiao-Qing Guan, Jiang-Jiang Qin
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License
CC BY-NC