Role of lactate metabolism and lactylation in gynecological malignancies (IMAGE)

Xia & He Publishing Inc.

Role of lactate metabolism and lactylation in gynecological malignancies

Caption

AARS, Alanyl-tRNA synthetase; AKT, protein kinase B; CC, cervical cancer; DCBLD1, discoidin, CUB, and LCCL domain-containing protein 1; EC, endometrial cancer; G6PD, glucose-6-phosphate dehydrogenase; H3K18, histone H3 lysine 18; H4K12, histone H4 lysine 12; HIF-1α, hypoxia-inducible factor-1α; HPV16-E6, human papillomavirus type 16 E6 protein; LDH, lactate dehydrogenase ; MCT, monocarboxylate transporter; MYC, myelocytomatosis viral oncogene homolog; OC, ovarian cancer; P53, tumor protein 53; PD-L1, programmed cell death ligand 1; PFKP, phosphofructokinase platelet-type; PI3K, phosphatidylinositol-3 kinase; PK, pyruvate kinase; PKG1, Protein kinase G1; PPP, pentose phosphate pathway; PTEN, phosphatase and tensin homolog; TCA, trichloroacetic acid; USP39, ubiquitin-specific peptidase 39.

Credit

Ying Zhou, Liang Chen

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License

CC BY-NC

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