Dihydroartemisinin Triggers Protective Cell Death in Liver Fibrosis via Epigenetic Change (IMAGE)
Caption
Dihydroartemisinin increases a chemical mark called H3K9ac on DNA in liver cells, opening the DNA to turn on the CHAC1 gene. This process is helped by a protein called ATF4, which activates CHAC1 transcription. The gene activation disrupts cellular balance, causing lipid damage and leading liver cells to die through ferroptosis, slowing fibrosis progression and offering new treatment avenues.
Credit
Professor Qian Li from the Medical School of Yangzhou University, China Image Source Link: http://doi.org/10.1097/CM9.0000000000003788
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