Dnmt1 regulates energy metabolism to ensure proper chondrocyte maturation and normal bone elongation. (IMAGE)

Ehime University

Dnmt1 regulates energy metabolism to ensure proper chondrocyte maturation and normal bone elongation.

Caption

Loss of Dnmt1 disrupted normal DNA methylation in chondrocytes, leading to increased expression of genes involved in cellular energy metabolism. As a result, metabolic abnormalities occurred, promoting the differentiation and calcification of growth plate chondrocytes and ultimately inhibiting bone growth. These findings suggest that proper maintenance of DNA methylation mediated by Dnmt1 during chondrocyte differentiation regulates intracellular energy metabolism through gene expression control, thereby maintaining the balance of chondrocyte differentiation and calcification and ensuring normal bone growth. [Illustrated by Taro Kuroda (ADRES, Ehime univ.)]

Credit

Yuta Yanagihara, Yuuki Imai, Ehime University

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