Researchers find a ‘hidden pocket’ to target nuclear receptors (IMAGE)

St. Jude Children's Research Hospital

Researchers find a ‘hidden pocket’ to target nuclear receptors

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Published today in Nature Communications, first author Andrew Huber, PhD, corresponding author Taosheng Chen, PhD, and second author Wenwei Lin, PhD, St. Jude Department of Chemical Biology and Therapeutics, uncovered a hidden binding pocket on the pregnane X receptor (PXR), paving the way for selective PROTAC therapies that target nuclear receptors while minimizing off-target effects.

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St. Jude Children's Research Hospital

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