Releasing the Brake on Purine Metabolism (IMAGE)

University of Oxford

Releasing the Brake on Purine Metabolism

Caption

Releasing the Brake on Purine Metabolism. NUDT5 binds and restrains PPAT, acting as a cellular handbrake to limit the production of DNA building blocks. Loss or mutation of NUDT5 releases the brake, boosting purine synthesis and giving cancer cells the fuel to resist treatment. Credit: Kilian Huber

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Kilian Huber

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Credit: Kilian Huber

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