LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas (IMAGE)
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Figure 1: LRIG1 expression negatively correlates with WHO grades of gliomas. Representative Western Blot can be seen in Figure 9. (A–E) Western blot analysis of LRIG1 protein level. LRIG1 expression is significantly higher in control tissue (A, p = 0.0004). Grade II gliomas showed a tendency towards a higher LRIG1 expression than grade III gliomas (B) and significantly higher expression than sec. GBMs (C, p = 0.0079). Grade III tended to have a higher expression of LRIG1 than secondary GBMs (D, n.s.)). Low grade gliomas had significantly higher protein levels than high grade gliomas (grade III and GBMs) (E, p = 0.0118). (F–J) PCR analysis of LRIG1 mRNA. LRIG1 expression tended to be higher in gliomas (F, n.s.). LRIG1 transcriptional level correlates with protein level. There was a significantly higher expression in grade II compared to grade III (G, p = 0.0096) and secondary GBMs (H, p < 0.0001). Grade III tended to have a higher LRIG1 expression than secondary GBMs (I, n.s.). Transcription was significantly higher in low-grade compared to high-grade gliomas (J, p < 0.0001). (Statistical significance is marked with *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001; Abbreviation: ns: not significant).
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