OSA or IH-induced exosomal donor cells and recipient cells. (IMAGE)
Caption
Obstructive Sleep Apnea (OSA) or Intermittent Hypoxia (IH) stimulates diverse donor cells (like macrophages and tumor cells) to release exosomes loaded with various signaling molecules (miRNAs, proteins, etc.). These exosomes act as messengers, transferring their cargo to a wide array of recipient cells (including endothelial cells, neurons, and adipocytes) to trigger pathological responses such as inflammation, cell activation, and proliferation.
Credit
Ruoyun Ouyang from Central South University
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License
CC BY-NC-ND