Synergistic Ferroptosis–Immunotherapy Nanoplatforms: Multidimensional Engineering for Tumor Microenvironment Remodeling and Therapeutic Optimization (IMAGE)
Caption
- First systematic integration: This work presents the first comprehensive outline of the synergistic potential of nanoparticle-enabled ferroptosis–immunotherapy strategies against malignancies, moving beyond studies solely focusing on ferroptosis induction or standalone nanotherapeutics in cancer.
- Multidimensional nanoplatform design: Establishes advanced design principles for functionalized nanoplatforms, including rational material selection, structural configuration, physicochemical modulation, multifunctional integration, and AI-enabled design, to overcome tumor microenvironment barriers and optimize ferroptosis–immunotherapy efficacy.
- Translational focus & AI integration: Provides a critical analysis of translational hurdles for ferroptosis–immunotherapy nanoplatforms across preclinical and clinical development, proposing actionable solutions while pioneering the integration of artificial intelligence into future nanoplatform design and onco-immunotherapy direction.
Credit
Xiao Wei*, Yanqiu Jiang, Feiyang Chenwu, Zhi Li, Jie Wan, Zhengxi Li, Lele Zhang, Jing Wang, Mingzhu Song*.
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Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND