Knowledge Mining Inspired Therapy of Osteoporosis by Magnetic Hydrogel Mediated Precise Stimulation of Vagus Nerve Under a Rotational Magnetic Field (IMAGE)

Tsinghua University Press

Knowledge Mining Inspired Therapy of Osteoporosis by Magnetic Hydrogel Mediated Precise Stimulation of Vagus Nerve Under a Rotational Magnetic Field

Caption

Significant relationship between vagus nerve and bone remodeling was identified through artificial intelligence (AI)-based knowledge mining. Iron oxide nanoparticles incorporated injectable hydrogels (termed M-Gels) were applied to rats' left neck vagus nerves, showing at least 20-week retention. Magnetic vagus nerve stimulation (mVNS) at 20 Hz twice daily for 16 weeks enhanced bone metabolism. AI analysis identified gut microbiota as a contributing factor, highlighting mVNS's potential for osteoporosis treatment.

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Nano Research, Tsinghua University Press

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