Switchbody: an antibody-based switch controlling enzyme activity by the trap-and-release of fused enzyme-derived fragment (IMAGE)

Institute of Science Tokyo

Switchbody: an antibody-based switch controlling enzyme activity by the trap-and-release of fused enzyme-derived fragment

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Researchers have developed a novel antibody-based enzyme switch that converts antibody–antigen binding into enzyme activity, paving the way from detection via bioluminescence to the control of cellular functions and the development of chemogenetic tools with potential therapeutic applications.

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Institute of Science Tokyo

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