TRPM1 Deficiency Induces Pathological Retinal Oscillations (IMAGE)

Ritsumeikan University

TRPM1 Deficiency Induces Pathological Retinal Oscillations

Caption

Loss of the TRPM1 ion channel in retinal ON bipolar cells disrupts communication with AII amacrine cells, causing anti-phase oscillations in retinal ganglion cells and structural remodeling of rod bipolar cell terminals. Computational modeling confirms that these changes are sufficient to trigger rhythmic retinal activity, a mechanism shared with degenerative diseases like retinitis pigmentosa.

Credit

Prof. Chieko Koike from Ritsumeikan University, Japan

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