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Toward the goal of generating high-quality embryo models in vitro, this study establishes a stepwise protocol to derive trophectoderm-like cells from mouse extended pluripotent stem (EPS) cells. These cells are then used to construct a transgene-free post-implantation embryo model, referred to as EPS-embryoids. The resulting EPS-embryoids recapitulate key developmental events of post-implantation embryogenesis, with a particular emphasis on gastrulation. This work presents a novel platform for modeling post-implantation mouse development in vitro, offering new opportunities to study the mechanisms governing early embryogenesis.
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HIGHER EDUCATON PRESS
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