Epitope mapping and neutralization activity of RBD-targeting antibodies against emerging SARS-CoV-2 variants/subvariants (IMAGE)

Tsinghua University Press

Epitope mapping and neutralization activity of RBD-targeting antibodies against emerging SARS-CoV-2 variants/subvariants

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Epitope mapping was performed using structural analysis to classify antibodies according to their binding sites on the receptor-binding domain (RBD). The neutralization activity of representative antibodies against emerging SARS-CoV-2 subvariants was evaluated using pseudovirus assays. The data reveal distinct resistance patterns among newly emerged Omicron sublineages and highlight a subset of antibodies maintaining broad neutralizing activity across divergent strains.

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hLife

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