St. Jude researchers found that ABCC4 interacts with a “neighborhood” of proteins through sticky protein regions called PDZ domains to restrict ABCC4’s movement. (IMAGE)

St. Jude Children's Research Hospital

St. Jude researchers found that ABCC4 interacts with a “neighborhood” of proteins through sticky protein regions called PDZ domains to restrict ABCC4’s movement.

Caption

Published this week in Nature Communications, corresponding author John Schuetz, PhD, (left) and co-first authors Sabina Ranjit, PhD (center) and Jingwen Zhu, PhD, St. Jude Department of Pharmacy &Pharmaceutical Sciences, revealed the protein ‘neighborhood’ which holds an ABC transporter in place to help regulate cyclic AMP signaling. 

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Courtesy of St. Jude Children's Research Hospital

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