This graphic shows mechanism diagram: USP16 was destabilized by iNOS-mediated S-nitrosylation, which degraded KDM1A protein via inhibiting its deubiquitination and consequently resulted in GSH exhaustion, aggravating CME-induced myocardial injury. (IMAGE)

Tsinghua University Press

This graphic shows mechanism diagram: USP16 was destabilized by iNOS-mediated S-nitrosylation, which degraded KDM1A protein via inhibiting its deubiquitination and consequently resulted in GSH exhaustion, aggravating CME-induced myocardial injury.

Caption

This graphic shows mechanism diagram: USP16 was destabilized by iNOS-mediated S-nitrosylation, which degraded KDM1A protein via inhibiting its deubiquitination and consequently resulted in GSH exhaustion, aggravating CME-induced myocardial injury.

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Chinese PLA General Hospital

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