Three-Step Click-Chemistry Method for Rapid PROTAC Assembly (IMAGE)

Tokyo University of Science

Three-Step Click-Chemistry Method for Rapid PROTAC Assembly

Caption

Researchers used a modular sequence of copper-catalyzed azide–alkyne cycloaddition (CuAAC), sulfur (VI) fluoride exchange (SuFEx), and Michael addition reactions to quickly assemble proteolysis-targeting chimeras (PROTACs) from simple building blocks. This approach simplifies the overall synthesis process and speeds up the development and testing of new protein-degrading drug candidates.

Credit

Dr. Suguru Yoshida from Tokyo University of Science, Japan Image link: https://doi.org/10.1093/bulcsj/uoaf115

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