A preclinical study identifies a key inflammatory mechanism driving liver injury and shows it could be targeted to develop new treatments for cirrhosis (IMAGE)

Universidad Miguel Hernandez de Elche

A preclinical study identifies a key inflammatory mechanism driving liver injury and shows it could be targeted to develop new treatments for cirrhosis

Caption

Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

 

Credit

Ángel-Gomis, E. et al (Biomedicine & Pharmacotherapy, 2025).

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.