ATR inhibition disrupts replication fork progression (IMAGE)

University of Texas M. D. Anderson Cancer Center

ATR inhibition disrupts replication fork progression

Caption

These two images demonstrate synthetic lethality with a non-responsive cell line (right) compared to a responder to ATR +PKMYT1 inhibition (left). As demonstrated by the long strands, the non-responder's DNA continues the process of replication fork progression normally, compared to the disrupted process demonstrated by the short and damaged strands.

Credit

The University of Texas MD Anderson Cancer Center

Usage Restrictions

none

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.