Comparation of calcitonin-calcitonin receptor signaling between humans and fish (IMAGE)
Caption
In fish, multiple HBD of CTR and stable ɑ-helix of calcitonin contribute to the high binding affinity and slow dissociation, thus triggering prolonged AC/cAMP signaling. In humans, RAMP dependent β-arrestin recruitment accelerates CTR internalization, disrupting AC/cAMP signaling despite similar initial AC activation kinetics.
HBD: hormone binding domain; CTR: calcitonin receptor; AC: adenylyl cyclase; cAMP: cyclic adenosine monophosphate; RAMP: receptor activity modifying proteins.
Credit
Yuying Yang, Jianmin Liu.
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