Mechanistic illustration of sevoflurane-induced inhibition of FAO in NSPCs impairing neurogenesis and cognitive function (IMAGE)

Chinese Medical Journals Publishing House Co., Ltd.

Mechanistic illustration of sevoflurane-induced inhibition of FAO in NSPCs impairing neurogenesis and cognitive function

Caption

Sevoflurane impairs neurogenesis and cognitive function by suppressing fatty acid β-oxidation (FAO) through the nuclear peroxisome proliferator-activated receptor α (PPARα)/carnitine palmitoyltransferase 1a (CPT1a) pathway in neural stem/progenitor cells (NSPCs) of the developing brain.

Credit

Pengyu Jia from The Second Affiliated Hospital of Xi’an Jiaotong University

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