Bridge Capture Permits Cost-Efficient, Rapid and Sensitive Molecular Precision Diagnostics (IMAGE)
Caption
Novel research in The Journal of Molecular Diagnostics details the new method, Bridge Capture, which advances cancer diagnostics and monitoring via liquid biopsies. The cell-free DNA isolated from blood is targeted using the Bridge Capture probe construct. The target sequence is copied into the probe construct, which is then circularized. Circularized DNA is linearly amplified by rolling circle amplification that produces long concatemers, which are subsequently digested into linear monomers. The monomers are indexed and sequenced.
Credit
The Journal of Molecular Diagnostics / Adamusová et al.
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CC BY-NC-ND