Schematic illustration of injectable nanorobot for precision cancer therapy (IMAGE)
Caption
Inspired by how a car uses an engine and a steering wheel to reach its destination, the nanorobot integrates two enzymatic functions. Urease works for propulsion by harnessing endogenous urea in bloodstream and tumor microenvironments, while catalase controls orientation by sensing the H2O2 concentration gradient typically existing in tumor microenvironments. By decoupling propulsion and orientation, the nanorobot exhibits ultrasensitive chemotaxis under physiological conditions. After intravenous injection, the nanorobots achieve significantly enhanced tumor-targeting efficiency and improved antitumor efficacy.
Credit
©Science China Press
Usage Restrictions
Use with credit.
License
Original content