Evaluation of [89Zr]Zr-DFO-zolbetuximab PET specificity in mouse models of GCa over multiple time points. (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Evaluation of [89Zr]Zr-DFO-zolbetuximab PET specificity in mouse models of GCa over multiple time points.

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Figure 2: Evaluation of [89Zr]Zr-DFO-zolbetuximab PET specificity in mouse models of GCa over multiple time points. (A and B) Maximum-intensity-projection serial PET/CT images for male nude mice implanted with GSU gastric tumors (white circles) imaged with [89Zr]Zr-DFO-zolbetuximab or [89Zr]Zr-DFO-IgG 1, 3, and 6 d after injection. (C and D) Quantitative in vivo biodistribution of [89Zr]Zr-DFO-zolbetuximab and [89Zr]Zr-DFO-IgG in tumor and selected tissues. ns = not significant on one-way ANOVA test.

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Image created by Dr. S Raheem and Dr. S Esfahani, et al., Massachusetts General Hospital, Boston, MA, USA.

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