Following a successful KPE expansion of K7 positive bile duct epithelium and transdifferentiating parenchymal intermediate hepatocytes (green color) in the vicinity of portal tracts are associated with liver fibrosis and NL survival. (IMAGE)

Zhejiang University

Following a successful KPE expansion of K7 positive bile duct epithelium and transdifferentiating parenchymal intermediate hepatocytes (green color) in the vicinity of portal tracts are associated with liver fibrosis and NL survival.

Caption

Following a successful KPE expansion of K7 positive bile duct epithelium and transdifferentiating parenchymal intermediate hepatocytes (green color) in the vicinity of portal tracts are associated with liver fibrosis and NL survival. Relative transcriptional abundance of activated HSC (aHSC) and macrophages reduces, CD8 T cells and natural killer (NK) cells remain unaltered, whereas cholangiocyte abundance shows an increasing trend. Many persistently highly overexpressed genes are involved with fibrogenesis, myofibroblast activation, and cholangiocyte deficiencies modulated by TGF-β signaling. aPF, activated portal fibroblast; ECM, extracellular matrix; KC, Kupffer cell; KPE, Kasai portoenterostomy; NL, native liver; SAM, scar-associated macrophage.

Credit

World Journal of Pediatric Surgery

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CC BY-NC

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