Characterizing Early Thrombin Generation in Cardiovascular Disease with a High-Sensitivity Coagulation Assay (IMAGE)

Kumamoto University

Characterizing Early Thrombin Generation in Cardiovascular Disease with a High-Sensitivity Coagulation Assay

Caption

Using a high-sensitivity blood test (SMAT) that measures initial thrombin generation (ITG)—the very first step of blood clot formation—the researchers analyzed blood samples from 771 patients with cardiovascular disease. The results showed that ITG clearly differed depending on the use of anticoagulant drugs (DOACs or warfarin). In addition, ITG was reduced in patients with chronic kidney disease, those undergoing dialysis, and patients with cancer, revealing disease-specific patterns of blood coagulation.

Credit

Fujiyama et al.

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CC BY-NC

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