Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications (IMAGE)
Caption
Inflammation and mitochondrial damage likely contribute significantly to this process, although the precise mechanisms require further investigation. In patients with cirrhosis, cardiac dysfunction is closely associated with disease severity, highlighting the importance of monitoring cardiac function and electrocardiograms in clinical practice. However, the EF values observed in BDL-treated mice did not align with the established diagnostic criteria for CCM in patients. This discrepancy is likely attributable to cardiac atrophy in these mice, whereas CCM in patients is typically characterized by myocardial hypertrophy and chamber dilation. Such differences should be taken into account in future mechanistic studies.
Credit
Yijie Ding, Yong Su, Chaoliang Ge
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CC BY-NC