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Journal of Dermatologic Science and Cosmetic Technology

Graphical Abstract

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Black ginseng extract (4 μg/mL) could inhibit the expression of MMP-1 in human foreskin fibroblasts damaged by inflammation. Additionally, 0.1% BGE could not only inhibit the secretion of PGE2 in a reconstructed 3D skin model damaged by SDS but also appear to have a reversing effect on aging. Meanwhile, the molecular docking results showed that ginsenoside Rg3, ginsenoside Rg5, and ginsenoside Rk1 had strong binding with target proteins of inflammation and aging. The results of the study showed that BGE has an effective effect in improving skin inflammation and aging. In addition, the specific pathways through which rare ginsenosides in BGE play a role in improving skin inflammatory aging need to be further explored.

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"Syoung Cosmetics Manufacturing Co., Ltd.,"

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