Innovative Strategies to Overcome Stability Challenges of Single‑Atom Nanozymes (IMAGE)
Caption
- This review uniquely provides an in-depth focus on the stability issues of single-atom nanozymes (SAzymes), covering multiple aspects such as metal atom clustering and active site loss, ligand bond breakage at high temperature, insufficient environment tolerance, biosecurity risks, and limited catalytic long-term stability.
- This review integrates and systematically discusses a wide range of potential strategies to overcome stability issues, including synthesis process optimization (space-limited strategy, coordination site design, bimetallic synergistic strategy, defect engineering strategy, atom stripping-capture), surface modification, and dynamic responsive design.
- To transform SAzymes from “star materials” of the laboratory into precise clinical tools for medicine, the authors propose the four-dimensional roadmap: structure-predictable, activity-tunable, biocompatible, and scalable.
Credit
Rong Guo, Qiuzheng Du, Yaping He, Haoan Wu*, Yu Zhang*, Ziwei Jing*.
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Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND