Antitumor mechanism of cGAS-STING pathway (IMAGE)
Caption
cGAS-STING signaling exerts antitumor functions in cancer cells in an autonomous and non-autonomous manner. On the one hand, OIS secretes SASP in response to oncogenic stimuli to prevent cell proliferation, and activation of the STING signaling pathway in tumor cells may also promote apoptosis in tumor cells. On the other hand, STING activation in tumor cells promotes downstream type I IFN transcription and allows crosstalk between tumor and neighboring immune cells to modulate antitumor immunity. DCs can capture tumor-associated antigens and subsequently initiate tumor-killing by CD8+ T cells. Macrophages can produce TNF-α and express high levels of CxCl10, CxCl11, NOS2, and other molecules. Stromal cells can also be effective against tumor angiogenesis by expressing IFN-β. cGAS: Cyclic GMP-AMP synthase; cGAMP: Cyclic GMPAMP; CIN: Chromosomal instability; CXCL: C-X-C Motif Chemokine Ligand; dsDNA: Double-stranded DNA; IFN: Interferon; ROS: Reactive oxygen species; SASP: Senescence-associated secretory phenotype; STING: Stimulator of interferon genes; NOS: Nitric Oxide Synthase.
Credit
Chinese Medical Journal
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