LD biogenesis and functions in TAMs (IMAGE)

Chinese Medical Journals Publishing House Co., Ltd.

LD biogenesis and functions in TAMs

Caption

TAMs upregulate CD36 and IL-1β induced MARCO to enhance the uptake of lipids (FAs, cholesterol, LDL) and EVs, driving LD biogenesis. This LD accumulation reinforces FAO and upregulates PI3K-γ, polarizing TAMs toward an anti-inflammatory phenotype with elevated PD-L1. These lipid-loaded TAMs promote tumor progression by secreting pro-angiogenic and migratory factors (CCL6 and VEGFA) and directly transferring SEs to tumor cells via ABCA1, fueling tumor cell proliferation. The upward arrow indicates an increase. The downward arrow indicates a decrease

Credit

Chinese Medical Journal

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CC BY-NC-ND

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