Efficacy of Insilico’s ISM0676 demonstrated in mice model (IMAGE)

InSilico Medicine

Efficacy of Insilico’s ISM0676 demonstrated in mice model

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In diet-induced obese (DIO) humanized GIPR mice, ISM0676 treatment led to significant body weight reduction along with improved body composition, as indicated by a higher lean mass-to-body weight ratio. After 27 days of dosing, ISM0676 achieved a 10.4% reduction in body weight from baseline, compared to 3% increase in the DIO vehicle group. Furthermore, when combined with Semaglutide, ISM0676 led to a substantially enhanced body weight loss of 31.3%.

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Insilico Medicine

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