Antibody transformation through single-amino-acid deletion (IMAGE)

Institute of Science Tokyo

Antibody transformation through single-amino-acid deletion

Caption

Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in maintaining antibody structure and immune function.

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Institute of Science Tokyo

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