Differences in the Binding Thermodynamics of Doxepin Isomers (IMAGE)

Tokyo University of Science

Differences in the Binding Thermodynamics of Doxepin Isomers

Caption

The findings show that considering conformational constraints and flexibility in designing ligands with optimized thermodynamic properties can lead to improved drugs with higher selectivity.

Credit

Professor Mitsunori Shiroishi from Tokyo University of Science, Japan Source link: https://pubs.acs.org/doi/10.1021/acsmedchemlett.5c00696

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