Single-cell landscape of GC under T-DXd treatment. (IMAGE)
Caption
Single-cell landscape of GC under T-DXd treatment. (A) Diagram of the workflow for single-cell sequencing. (B–D) UMAP embedding plots of all cells colored by treatment, treatment response, and patient samples. The plot visualizes the distribution and clustering of single cells based on treatment (left), treatment response (middle), and different samples (right), with different colors representing distinct cell types. (E) Canonical marker genes for 11 major cell types, aiding in the identification and characterization of different cell populations. (F) UMAP embedding plots of all cells grouped into 11 major types. (G) Cell proportions visualized by treatment or not. This visualization provides an overview of the relative abundance of different cell types (Wilcoxon rank-sum test). (H) Cell proportions visualized by subject. This visualization provides an overview of the relative abundance of different cell types within each sample. (I) UMAP embedding plots of all cells grouped into 30 subtypes.
Credit
Precision Clinical Medicine
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