Disruption of transthyretin amyloid deposits by a pomegranate-derived natural compound (IMAGE)
Caption
Researchers identified a bioactive compound called PGG (1,2,3,4,6-penta-O-galloyl-β-D-glucose) from pomegranate (Punica granatum) leaf and branch extracts through plant library screening. Laboratory (in vitro), animal model (in vivo), and patient-derived (ex vivo) experiments demonstrated that PGG breaks down transthyretin (TTR) amyloid fibrils, reduces amyloid deposits, and improves healthspan and lifespan in a TTR-expressing C. elegans model. These findings suggest a promising natural approach for targeting TTR amyloidosis.
Image from Kagami A. et al., “Glycosidic scaffold bearing multiple galloyl moieties from pomegranate disrupts transthyretin amyloids,” iScience (2026). Licensed under CC BY 4.0.
Credit
Kagami A. et al.
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CC BY