Internalization of isolated MSC-derived mitochondria via multiple endocytic pathways enhances cellular function (IMAGE)

Tokyo University of Science

Internalization of isolated MSC-derived mitochondria via multiple endocytic pathways enhances cellular function

Caption

Isolated mitochondria taken up by mesenchymal stromal cells (MSCs) increase cell proliferation, antioxidant capacity, and mitochondrial respiration. Uptake occurred in a time-dependent manner and involves multiple endocytic pathways, including clathrin-, caveolin-, CLIC/GEEC-, and actin-dependent mechanisms. These findings show that internalized mitochondria remain functional and improve cellular bioenergetics.

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Associate Professor Kosuke Kusamori from Tokyo University of Science, Japan

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