Diagram of the regulatory mechanism by which H3K56 lactylation attenuates osteoarthritis. (IMAGE)

Burns & Trauma

Diagram of the regulatory mechanism by which H3K56 lactylation attenuates osteoarthritis.

Caption

αKG induces a relatively reductive state within chondrocytes, promotes the extracellular lactate shuttle into the cells and H3K56 lactylation modification, and positively regulates the expression of HIF-1α and type II collagen synthesis within chondrocytes.

Credit

Burns & Trauma

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CC BY-NC

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