A Shape-Memory, Metal–Polyphenol–Coated Scaffold for Sequential Repair of Infected Bone Defects. (IMAGE)

Burns & Trauma

A Shape-Memory, Metal–Polyphenol–Coated Scaffold for Sequential Repair of Infected Bone Defects.

Caption

A Shape-Memory, Metal–Polyphenol–Coated Scaffold for Sequential Repair of Infected Bone Defects. Schematic illustration of the design and therapeutic mechanism of the PT/CHA@TA-Mg scaffold. Citric acid–modified hydroxyapatite (CHA) is incorporated into a PLLA-TMC shape-memory polymer to enable low-temperature 3D printing and body-temperature–triggered shape recovery for minimally invasive implantation and adaptive defect filling. A tannic acid–magnesium (TA-Mg) metal–polyphenol network is assembled on the scaffold surface to provide antibacterial activity and immunomodulation. The resulting bionic multi-level porous structure supports sequential antibacterial action, inflammation regulation, and osteogenic regeneration, ultimately promoting effective repair of infectious bone defects.

Credit

Burns & Trauma

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CC BY-NC

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