Cell-Surface AMPA Receptor Distribution Predicts Antidepressant Response to Ketamine (IMAGE)

YCU Advanced Medical Research Center

Cell-Surface AMPA Receptor Distribution Predicts Antidepressant Response to Ketamine

Caption

Positron emission tomography (PET) images using the novel tracer [¹¹C]K-2 visualize cell-surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) density in the living human brain. Patients with treatment-resistant depression show region-specific AMPAR alterations compared with healthy controls. Ketamine-induced AMPAR changes across cortical and subcortical regions correlate with symptom improvement, indicating that AMPAR dynamics underlie ketamine’s antidepressant effects.

Credit

Professor Takuya Takahashi from Yokohama City University Graduate School of Medicine, Japan, and Dr. Hiroyuki Uchida from Keio University School of Medicine, Japan

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