NuSAP: The “centriole bodyguard” of the cell (IMAGE)
Caption
A two-step recruitment model based on the findings for the CEP57-CEP63-CEP152 complex during a single cell cycle. (A) During S to G2 phase, CEP57 is gradually recruited to the procentriole, crucial for precise engagement between mother and procentrioles. This recruitment process is finely regulated by NuSAP and centriolar structural integrity. (B) In the absence of NuSAP, with centriole tubulin instability, CEP57 recruitment to procentrioles during S to G2 phase is impaired, leading to disorganized pericentriolar material (PCM) structure and premature centriole disengagement.
Credit
[Created in BioRender. Liou Y. (2026) https://BioRender.com/pbzrubb]
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