D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice (IMAGE)
Caption
Figure 5. The SAAR diet, but not BSO, increases marrow adipocytes in tibiae. Micro-CT (first row) and photomicrographs (second row) of osmium-stained images of tibiae are shown in (A). Compared with the CD, the SAAR diet increased marrow adipocytes at volumes of interest 2 and 4, but not at volume of interest 3 (B–D, SAAR > CD). NAC reversed the increase in SAAR at all volumes of interest (B–D, SAAR > [CD = NAC]), while BSO had no effect (CD = BSO). Sample sizes and statistical methods are similar to those in Figure 1. Note: Volume of interest-1 is not shown in the figure.
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