CD47 and its common interaction partners (IMAGE)
Caption
(A) CD47 associates with SIRPα on immune cells via its N-terminal domain, triggering the phosphorylation of the ITIMs and subsequent recruitment of SHP1/2, thereby inhibiting phagocytosis. (B) TSP1 interacts with CD47 through its C-terminal, and the TSP1-CD47 signalling activates the P38 MAPK pathway and CKIs, leading to the inhibition of CDKs and the induction of senescence. Additionally, the TSP1-CD47 association has been linked to the suppression of the VEGFR and NO signalling, thereby inhibiting angiogenesis and promoting mitochondrial dysfunction. (C) CD47 associates with the α4β1/αvβ3 integrins to activate the FAC, promoting cell migration and proliferation through stimulation of Rac1 or MEK/ERK pathways. This figure is created using Biorender.com. α4β1/αvβ3 integrin, integrin alpha-4 beta-1 and integrin alpha-v beta-3; CD47, cluster of differentiation 47; CDC42, cell division cycle 42; CDKs, cyclin-dependent kinases; CKIs, cyclin-dependent kinase inhibitors; ERK, extracellular signal-regulated kinase; FAC, focal adhesion complex; ITIMs, tyrosine-based inhibition motifs; MEK, mitogen-activated protein kinase kinase (MAP2K); MAPK, mitogen-activated protein kinase; NO, nitric oxide; Rac1, ras-related c3 botulinum toxin substrate 1; Raf, rapidly accelerated fibrosarcoma kinase; Ras, rat sarcoma virus oncogene; ROS, reactive oxygen species; SHP, Src homology-2 domain-containing protein tyrosine phosphatase; SIRPα, signal regulatory protein alpha; TSP1, thrombospondin-1; VEGFR, vascular endothelial growth factor receptor.
Credit
By Josephine Otuagomah, Alana Newcomb, Taesik Gwag, and Shuxia Wang.
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Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC