Pharmacological activation of hypoxia signaling improves metabolism and bone health in obesity (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Pharmacological activation of hypoxia signaling improves metabolism and bone health in obesity

Caption

Roxadustat-mediated activation of hypoxia-inducible factor signaling in obesity-induced mice reduced weight gain, improved glucose metabolism, and protected bone by limiting marrow fat accumulation, preserving vasculature, and enhancing fracture healing.

Credit

Prof. Christa Maes from KU Leuven, Belgium Image source link: https://www.nature.com/articles/s41413-025-00503-3

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CC BY

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