A novel macrophage subset Mrep for muscle regeneration and heterotopic ossification in FOP (IMAGE)
Caption
Mrep accumulates in damaged muscle tissue and promotes muscle regeneration by acting on muscle satellite cells through activin A. While Mrep performs beneficial functions in normal muscle repair, in FOP it stimulates mutant ACVR1 through activin A, consequently acting as a detrimental factor that triggers heterotopic ossification. Therefore, therapeutic approaches that suppress Mrep accumulation or function represent promising treatments for preventing heterotopic ossification in FOP.
Credit
Kazuo Okamoto (Kanazawa University)
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