BCMA as a Key Driver in IgA Nephropathy (IMAGE)

Tsinghua University Press

BCMA as a Key Driver in IgA Nephropathy

Caption

In the gut mucosa of IgAN patients, expanded IgA+ plasma cells highly express BCMA, supported by APRIL signals, leading to excess pathogenic IgA and kidney injury. Therapeutic depletion of these BCMA+ cells cuts off this survival signal, reducing IgA production and alleviating kidney damage.

Credit

hLife

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.